Across TCGA cell cohorts, HBD mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HBD-associated genes across cancer lineages are ZNF831, CST8, and PZP. Each is linked with HBD in more than 1 cancer types. Because this analysis shows association rather than direction, both HBD-to-partner and partner-to-HBD results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HBD→partner) and Y-score (partner→HBD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF831 →	+0.018	+4.273	<.001	.006	3	1
LARGE_INTESTINE	CST8 →	+0.021	+4.415	<.001	.007	3	1
LARGE_INTESTINE	PZP →	+0.030	+4.467	<.001	.004	3	1
LARGE_INTESTINE	CDX4 →	+0.014	+5.217	<.001	<.001	3	1
LARGE_INTESTINE	FIGLA →	+0.037	+4.415	<.001	.007	3	1
LARGE_INTESTINE	DEFB132 →	+0.074	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

HBD survival (RNA) · tumor vs normal (RNA) · all HBD data types