HAVCR2

Across TCGA pan-cancer cohorts, HAVCR2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HAVCR2 data layer compared with 23 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HAVCR2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated HAVCR2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where HAVCR2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.858	0.554	.008	20	view →
PDAC	DFS	Tertile	All	0.218	0.646	.005	17	view →
LSCC	DFS	Tertile	III,IV	0.921	0.579	.040	5	view →
CCRCC	DFS	Median	All	1.000	0.724	.014	3	view →
UCEC	DFS	Quartile	All	0.795	1.000	.021	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HAVCR2–HNSC (OS)

Open the HNSC breakdown →