HAVCR2

Across TCGA cell cohorts, HAVCR2 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HAVCR2-associated genes across cancer lineages are HAND1, ECRG4, and ZNF831. Each is linked with HAVCR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAVCR2-to-partner and partner-to-HAVCR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HAND1 grouped by HAVCR2-low versus HAVCR2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAVCR2→partner) and Y-score (partner→HAVCR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HAND1 →	+1.243	+3.632	<.001	.003	3	1
LARGE_INTESTINE	ECRG4 →	+0.111	+3.373	.009	.007	3	1
LARGE_INTESTINE	ZNF831 →	+0.011	+3.103	<.001	.004	3	1
LARGE_INTESTINE	CDX4 →	+0.007	+3.217	.001	.006	3	1
LARGE_INTESTINE	OR4F21 →	+0.201	+4.141	<.001	<.001	3	1
LARGE_INTESTINE	FAM153B →	+0.524	+3.618	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

HAND1 by HAVCR2 expression — LARGE_INTESTINE

Explore this box plot interactively →