HAVCR1

Across TCGA patient cohorts, HAVCR1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAVCR1-associated genes across cancer lineages are Cyclin-E1, ERK2, and Fibronectin. Each is linked with HAVCR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAVCR1-to-partner and partner-to-HAVCR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E1 grouped by HAVCR1-low versus HAVCR1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAVCR1→partner) and Y-score (partner→HAVCR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Cyclin-E1 →	+0.693	+3.000	<.001	.036	3	1
UCEC	ERK2 →	+0.203	+3.169	.013	.018	3	1
UCEC	Fibronectin →	-0.360	-2.575	.010	.010	3	1
UCEC	GATA6 →	-0.185	-2.108	.006	.018	3	1
UCEC	INPP4B →	-0.316	-1.874	.021	.049	3	1
UCEC	JNK2 →	+0.348	+3.331	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Cyclin-E1 by HAVCR1 expression — LUAD

Explore this box plot interactively →