HAUS8

Across TCGA patient cohorts, HAUS8 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAUS8-associated genes across cancer lineages are JNK_pT183_Y185, PKC-b-II_pS660, and c-Met_pY1235. Each is linked with HAUS8 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAUS8-to-partner and partner-to-HAUS8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by HAUS8-low versus HAUS8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAUS8→partner) and Y-score (partner→HAUS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.199	-3.700	.001	.001	3	2
UCEC	PKC-b-II_pS660 →	-0.235	-2.247	.020	.001	3	2
UCEC	c-Met_pY1235 →	+0.098	+2.736	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.197	-1.502	.033	.030	3	1
UCEC	ERK2 →	+0.203	+1.502	.004	.030	3	1
UCEC	FoxM1 →	+0.213	+1.847	.025	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

JNK_pT183_Y185 by HAUS8 expression — UCEC

Explore this box plot interactively →