HAUS6

Across TCGA pan-cancer cohorts, HAUS6 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HAUS6 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher HAUS6 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HAUS6 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

PDAC, LSCC, and LUAD are the cancer types where HAUS6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.692	0.941	.001	41	view →
LSCC	OS	Tertile	All	0.976	0.710	<.001	39	view →
LUAD	DFS	Tertile	II,III,IV	0.986	0.696	<.001	24	view →
HNSC	OS	Tertile	All	0.575	0.804	.009	8	view →
GBM	OS	Median	All	0.281	0.464	.029	4	view →
UCEC	DFS	Tertile	All	0.761	0.925	.036	2	view →
CCRCC	DFS	Median	II,III,IV	0.801	0.953	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

HAUS6–PDAC (OS)

Open the PDAC breakdown →