HAUS6

Across TCGA patient cohorts, HAUS6 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAUS6-associated genes across cancer lineages are GAPDH, Cyclin-B1, and GSK-3a-b_pS21_S9. Each is linked with HAUS6 in more than 2 cancer types. Because this analysis shows association rather than direction, both HAUS6-to-partner and partner-to-HAUS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by HAUS6-low versus HAUS6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAUS6→partner) and Y-score (partner→HAUS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.401	+1.765	.021	.013	3	3
UCEC	Cyclin-B1 →	+0.493	+2.115	.006	.016	3	3
BLCA	GSK-3a-b_pS21_S9 →	+0.386	+3.000	.034	.036	3	2
UCEC	EGFR_pY1068 →	-0.197	-1.222	.015	.035	3	2
UCEC	eIF4E →	+0.176	+1.716	.010	.003	3	2
UCEC	FASN →	+0.264	+1.874	.039	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

GAPDH by HAUS6 expression — UCEC

Explore this box plot interactively →