HAUS5

Across TCGA patient cohorts, HAUS5 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAUS5-associated genes across cancer lineages are A-Raf_pS299, FoxM1, and JNK_pT183_Y185. Each is linked with HAUS5 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAUS5-to-partner and partner-to-HAUS5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by HAUS5-low versus HAUS5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAUS5→partner) and Y-score (partner→HAUS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.186	-3.700	<.001	.001	3	2
UCEC	FoxM1 →	+0.378	+3.247	<.001	<.001	3	2
UCEC	JNK_pT183_Y185 →	-0.189	-2.074	.003	.005	3	2
UCEC	Shc_pY317 →	-0.164	-2.584	.004	.001	3	2
UCEC	STAT3_pY705 →	-0.562	-2.999	<.001	<.001	3	2
UCEC	ATM →	-0.475	-3.156	.006	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

A-Raf_pS299 by HAUS5 expression — UCEC

Explore this box plot interactively →