HAS3

Across TCGA patient cohorts, HAS3 mutation is significantly associated with the RNA expression of many other genes, with 3,230 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAS3-associated genes across cancer lineages are RPL23AP36, PSKH2, and TRAJ47. Each is linked with HAS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAS3-to-partner and partner-to-HAS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL23AP36 grouped by HAS3-low versus HAS3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAS3→partner) and Y-score (partner→HAS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RPL23AP36 →	+0.114	+4.133	.005	.004	3	2
HNSC	PSKH2 →	+0.054	+3.301	.005	.008	3	2
UCEC	TRAJ47 →	+0.429	+1.816	<.001	.002	3	2
UCEC	OR11J5P →	+0.009	+3.620	<.001	.009	3	2
HNSC	RNU6-6P →	+0.429	+3.871	.003	.004	3	2
UCEC	FGF21 →	+0.342	+1.661	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,230 associations by consensus.

RPL23AP36 by HAS3 expression — CESC

Explore this box plot interactively →