HAS3

Across TCGA patient cohorts, HAS3 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAS3-associated genes across cancer lineages are eEF2, Rad50, and VHL. Each is linked with HAS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAS3-to-partner and partner-to-HAS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by HAS3-low versus HAS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAS3→partner) and Y-score (partner→HAS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.329	+3.321	.012	.009	3	2
UCEC	Rad50 →	-0.185	-1.502	.037	.030	3	2
UCEC	VHL →	-0.793	-1.906	.001	.015	3	2
UCEC	ATM →	-0.620	-2.247	<.001	.001	3	2
UCEC	Bad_pS112 →	-0.178	-1.986	.009	.029	3	2
UCEC	4E-BP1 →	+0.329	+2.730	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

eEF2 by HAS3 expression — UCEC

Explore this box plot interactively →