HAS1

Across TCGA pan-cancer cohorts, HAS1 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated HAS1 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher HAS1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HAS1 expression acts as an unfavorable survival marker, although some lineages such as SCLC and COAD show a favorable association.

THCA, ACC, and DLBC are the cancer types where HAS1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Median	All	0.043	0.950	<.001	36	view →
ACC	DFS	Median	All	0.046	0.753	<.001	36	view →
DLBC	OS	Median	II,III,IV	0.172	0.949	<.001	30	view →
SCLC	DFS	Median	All	1.000	0.213	.021	7	view →
PRAD	DFS	Median	All	0.617	0.886	.041	6	view →
BLCA	DFS	Median	III,IV	0.210	0.574	.035	3	view →
LIHC	OS	Median	All	0.374	0.780	.001	3	view →
COAD	DFS	Median	All	0.915	0.499	.042	2	view →
SKCM	DFS	Median	II,III,IV	1.000	0.668	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

HAS1–THCA (OS)

Open the THCA breakdown →