HAS1

Across TCGA cell cohorts, HAS1 mutation is significantly associated with the RNA expression of many other genes, with 53 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HAS1-associated genes across cancer lineages are OR1L3, DRD3, and CCDC60. Each is linked with HAS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAS1-to-partner and partner-to-HAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by HAS1-low versus HAS1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAS1→partner) and Y-score (partner→HAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR1L3 →	+0.034	+4.029	.002	.009	3	2
OESOPHAGUS	DRD3 →	+0.036	+4.906	<.001	.006	3	1
OVARY	CCDC60 →	+0.064	+4.228	<.001	.006	3	1
OVARY	C1orf146 →	+0.040	+4.450	<.001	.004	3	1
LUNG_NSCLC_LUAD	LYZL1 →	+0.018	+3.472	<.001	.004	3	1
LUNG_NSCLC_LUAD	HNRNPCL4 →	+0.014	+3.201	.007	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

OR1L3 by HAS1 expression — OVARY

Explore this box plot interactively →