HARS2

Across TCGA patient cohorts, HARS2 mutation is significantly associated with the RNA expression of many other genes, with 3,114 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HARS2-associated genes across cancer lineages are RNA5SP391, ATP5MGP7, and SKA1. Each is linked with HARS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HARS2-to-partner and partner-to-HARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP391 grouped by HARS2-low versus HARS2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HARS2→partner) and Y-score (partner→HARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP391 →	+0.152	+5.003	<.001	.002	3	3
KIRP	ATP5MGP7 →	+0.266	+4.967	.008	.009	3	2
UCEC	SKA1 →	+0.736	+2.831	<.001	.001	3	2
UCEC	MED27 →	+0.360	+2.479	.008	.001	3	2
UCEC	SGO2 →	+0.641	+2.436	.004	.002	3	2
UCEC	MON1A →	+0.373	+3.332	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,114 associations by consensus.

RNA5SP391 by HARS2 expression — SKCM

Explore this box plot interactively →