HARS2

Across TCGA patient cohorts, HARS2 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HARS2-associated genes across cancer lineages are STAT3_pY705, ATM, and GATA6. Each is linked with HARS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HARS2-to-partner and partner-to-HARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by HARS2-low versus HARS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HARS2→partner) and Y-score (partner→HARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.355	-2.574	.001	.010	3	2
UCEC	ATM →	-0.453	-3.459	.022	.005	3	2
UCEC	GATA6 →	-0.151	-2.693	.030	.006	3	1
UCEC	P-Cadherin →	-0.167	-3.169	.007	.018	3	1
UCEC	PRAS40_pT246 →	+0.171	+1.598	.023	.044	3	1
UCEC	Rab25 →	-0.301	-2.115	.037	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

STAT3_pY705 by HARS2 expression — UCEC

Explore this box plot interactively →