HARS2

Across TCGA cell cohorts, HARS2 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HARS2-associated genes across cancer lineages are GPR26, SCGB3A2, and OR9K2. Each is linked with HARS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HARS2-to-partner and partner-to-HARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR26 grouped by HARS2-low versus HARS2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HARS2→partner) and Y-score (partner→HARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GPR26 →	+0.077	+5.539	<.001	.003	3	1
BLOOD_Leukemia	SCGB3A2 →	+0.144	+4.922	<.001	.009	3	1
BLOOD_Leukemia	OR9K2 →	+0.029	+5.539	<.001	.003	3	1
BLOOD_Leukemia	TRIM60 →	+0.039	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR10Q1 →	+0.032	+5.969	<.001	.001	3	1
BLOOD_Leukemia	OR52L1 →	+0.058	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

GPR26 by HARS2 expression — BLOOD_Leukemia

Explore this box plot interactively →