HARS1

Across TCGA patient cohorts, HARS1 mutation is significantly associated with the RNA expression of many other genes, with 3,011 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HARS1-associated genes across cancer lineages are LINC02713, SPANXN2, and RPPH1-2P. Each is linked with HARS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HARS1-to-partner and partner-to-HARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02713 grouped by HARS1-low versus HARS1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HARS1→partner) and Y-score (partner→HARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC02713 →	+0.050	+5.306	<.001	.006	3	2
CESC	SPANXN2 →	+0.088	+6.569	<.001	.001	3	2
BRCA	RPPH1-2P →	+0.103	+7.731	<.001	.009	3	2
UCEC	XPC →	+0.566	+3.491	.003	.002	3	2
UCEC	SLC4A1AP →	+0.476	+3.470	.004	.002	3	2
UCEC	MYH9 →	+0.518	+3.223	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,011 associations by consensus.

LINC02713 by HARS1 expression — CESC

Explore this box plot interactively →