HARS1

Across TCGA cell cohorts, HARS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,642 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HARS1-associated GO terms across cancer lineages are Double-strand break repair via nonhomologous end joining, Protein-RNA covalent cross-linking repair, and Microtubule polymerization. Each is linked with HARS1 in more than 14 cancer types. Because this analysis shows association rather than direction, both HARS1-to-partner and partner-to-HARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Double-strand break repair via nonhomologous end joining grouped by HARS1-low versus HARS1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HARS1→partner) and Y-score (partner→HARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via nonhomologous end joining →	+0.078	+0.960	<.001	<.001	3	15
BLOOD_Myeloma	Protein-RNA covalent cross-linking repair →	+0.119	+0.803	.001	<.001	3	14
URINARY_TRACT	Microtubule polymerization →	+0.099	+0.979	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome organization →	+0.074	+0.635	<.001	<.001	3	13
PANCREAS	Positive regulation of rRNA processing →	+0.136	+0.780	<.001	<.001	3	13
PANCREAS	DNA replication initiation →	+0.214	+0.833	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,642 associations by consensus.

Double-strand break repair via nonhomologous end joining by HARS1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →