Across TCGA pan-cancer cohorts, HAR1A RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated HAR1A data layer.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher HAR1A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HAR1A expression acts as an unfavorable survival marker, although some lineages such as LGG and ACC show a favorable association.
KIRC, LGG, and ACC are the cancer types where HAR1A RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.