HAPLN1

Across TCGA patient cohorts, HAPLN1 protein abundance is significantly associated with the protein abundance of many other proteins, with 14,306 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HAPLN1-associated proteins across cancer lineages are ACAN, ANTXR1, and SAMHD1. Each is linked with HAPLN1 in more than 5 cancer types. Because this analysis shows association rather than direction, both HAPLN1-to-partner and partner-to-HAPLN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HAPLN1 versus ACAN in LSCC, with a Pearson correlation of 0.71.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HAPLN1→partner) and Y-score (partner→HAPLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ACAN →	+1.728	+1.442	<.001	<.001	3	6
LUAD	ANTXR1 →	+0.512	+0.790	<.001	<.001	3	4
UCEC	SAMHD1 →	-0.415	-0.532	<.001	<.001	3	4
PDAC	SEPTIN1_S206 →	-0.756	-1.048	<.001	<.001	3	4
UCEC	PSMB10 →	-0.428	-0.652	.003	<.001	3	4
GBM	MTREX →	-0.251	-0.690	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,306 associations by consensus.

HAPLN1 vs ACAN — LSCC

Explore this scatter interactively →