HAPLN1

Across TCGA patient cohorts, HAPLN1 mutation is significantly associated with the RNA expression of many other genes, with 2,535 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAPLN1-associated genes across cancer lineages are MRPL37, PIGW, and YRDC. Each is linked with HAPLN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both HAPLN1-to-partner and partner-to-HAPLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL37 grouped by HAPLN1-low versus HAPLN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAPLN1→partner) and Y-score (partner→HAPLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL37 →	+0.437	+2.828	.001	.001	3	4
UCEC	PIGW →	+0.526	+2.534	.001	<.001	3	3
UCEC	YRDC →	+0.403	+2.332	.002	.003	3	3
LUAD	PDXP →	+0.588	+3.402	<.001	.004	3	3
LUAD	RBM15B →	+0.380	+3.375	.005	.004	3	3
UCEC	CTU2 →	+0.583	+2.272	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,535 associations by consensus.

MRPL37 by HAPLN1 expression — UCEC

Explore this box plot interactively →