HAPLN1

Across TCGA cell cohorts, HAPLN1 protein abundance is significantly associated with the go_rna of many other GO terms, with 1,337 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible HAPLN1-associated GO terms across cancer lineages are Negative regulation of hormone biosynthetic process, Regulation of extrinsic apoptotic signaling pathway, and Primary amino compound biosynthetic process. Each is linked with HAPLN1 in more than 4 cancer types. Because this analysis shows association rather than direction, both HAPLN1-to-partner and partner-to-HAPLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of hormone biosynthetic process grouped by HAPLN1-low versus HAPLN1-high in SKIN.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HAPLN1→partner) and Y-score (partner→HAPLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Negative regulation of hormone biosynthetic process →	+1.235	+1.131	<.001	<.001	3	5
LARGE_INTESTINE	Regulation of extrinsic apoptotic signaling pathway →	+0.082	+0.860	.005	.002	3	5
STOMACH	Primary amino compound biosynthetic process →	-1.404	-1.022	<.001	<.001	3	5
LUNG_NSCLC_LUAD	Neuroendocrine cell differentiation →	+0.311	+1.087	<.001	<.001	3	4
KIDNEY	Regulation of stress-activated MAPK cascade →	+0.110	+1.424	<.001	.002	3	4
LUNG_NSCLC_LUSC	Isoprenoid catabolic process →	-1.533	-0.949	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,337 associations by consensus.

Negative regulation of hormone biosynthetic process by HAPLN1 expression — SKIN

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