HAPLN1

Across TCGA cell cohorts, HAPLN1 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HAPLN1-associated genes across cancer lineages are PRR23B, MDFIC2, and FAM216B. Each is linked with HAPLN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAPLN1-to-partner and partner-to-HAPLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR23B grouped by HAPLN1-low versus HAPLN1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAPLN1→partner) and Y-score (partner→HAPLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PRR23B →	+0.003	+4.078	<.001	.009	3	2
SKIN	MDFIC2 →	+0.155	+4.977	<.001	.007	3	1
BLOOD_Leukemia	FAM216B →	+0.133	+3.944	<.001	.006	3	1
BLOOD_Leukemia	SLC9A4 →	+0.022	+4.147	<.001	.008	3	1
LARGE_INTESTINE	C6orf118 →	+0.124	+3.378	<.001	.001	3	1
LARGE_INTESTINE	MYH8 →	+0.056	+2.657	.009	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

PRR23B by HAPLN1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →