HAP1

Across TCGA patient cohorts, HAP1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAP1-associated genes across cancer lineages are HER3_pY1289, CD49b, and YAP_pS127. Each is linked with HAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAP1-to-partner and partner-to-HAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3_pY1289 grouped by HAP1-low versus HAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAP1→partner) and Y-score (partner→HAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3_pY1289 →	+0.089	+2.341	.014	.019	3	2
UCEC	CD49b →	-0.284	-2.209	.018	.011	3	2
SKCM	YAP_pS127 →	-0.401	-3.000	.031	.035	3	1
UCEC	EGFR →	-0.179	-3.000	.008	.036	3	1
UCEC	A-Raf_pS299 →	-0.124	-3.584	.014	.002	3	1
UCEC	FOXO3a_pS318_S321 →	-0.140	-2.222	.008	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

HER3_pY1289 by HAP1 expression — UCEC

Explore this box plot interactively →