HAP1

Across TCGA cell cohorts, HAP1 mutation is significantly associated with the RNA expression of many other genes, with 282 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HAP1-associated genes across cancer lineages are DPRX, CST9L, and FXYD4. Each is linked with HAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAP1-to-partner and partner-to-HAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPRX grouped by HAP1-low versus HAP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAP1→partner) and Y-score (partner→HAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DPRX →	+0.063	+4.060	<.001	.003	3	2
SKIN	CST9L →	+0.035	+5.415	<.001	.004	3	1
SKIN	FXYD4 →	+0.164	+4.977	<.001	.007	3	1
SKIN	IFNL2 →	+0.040	+6.022	<.001	.001	3	1
SKIN	TAS2R60 →	+0.078	+5.415	<.001	.004	3	1
SKIN	TXNDC8 →	+0.025	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 282 associations by consensus.

DPRX by HAP1 expression — BLOOD_Leukemia

Explore this box plot interactively →