HAND1

Across TCGA patient cohorts, HAND1 mutation is significantly associated with the RNA expression of many other genes, with 333 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAND1-associated genes across cancer lineages are RNA5SP415, MTND2P38, and SQSTM1P1. Each is linked with HAND1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAND1-to-partner and partner-to-HAND1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP415 grouped by HAND1-low versus HAND1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAND1→partner) and Y-score (partner→HAND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP415 →	+0.839	+2.681	<.001	.008	3	2
LUAD	MTND2P38 →	+0.030	+5.481	.004	.005	3	2
SARC	SQSTM1P1 →	+0.060	+5.345	.001	.005	3	2
SKCM	RNU4-49P →	+0.291	+3.801	<.001	.007	3	1
UCEC	ZC3H18 →	+0.521	+3.354	.004	.005	3	1
UCEC	SYVN1 →	+0.551	+3.201	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 333 associations by consensus.

RNA5SP415 by HAND1 expression — UCEC

Explore this box plot interactively →