HAND1

Across TCGA patient cohorts, HAND1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAND1-associated genes across cancer lineages are PEA-15_pS116, Rad50, and Annexin-1. Each is linked with HAND1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAND1-to-partner and partner-to-HAND1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PEA-15_pS116 grouped by HAND1-low versus HAND1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAND1→partner) and Y-score (partner→HAND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PEA-15_pS116 →	-0.485	-3.169	.011	.020	3	1
UCEC	Rad50 →	-0.414	-3.156	.001	.018	3	1
UCEC	Annexin-1 →	+0.734	+2.827	.011	.035	3	1
UCEC	STAT3_pY705 →	-0.302	-3.169	.036	.020	3	1
UCEC	14-3-3_zeta →	-0.225	-3.143	.047	.020	3	1
UCEC	Di-Ras3 →	-0.205	-3.169	.011	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PEA-15_pS116 by HAND1 expression — UCEC

Explore this box plot interactively →