HAND1

Across TCGA cell cohorts, HAND1 RNA expression is significantly associated with the go_rna of many other GO terms, with 311 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible HAND1-associated GO terms across cancer lineages are RNA splicing, via transesterification reactions, RNA splicing, via transesterification reactions with bulged adenosine as nucleophile, and mRNA splicing, via spliceosome. Each is linked with HAND1 in more than 5 cancer types. Because this analysis shows association rather than direction, both HAND1-to-partner and partner-to-HAND1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA splicing, via transesterification reactions grouped by HAND1-low versus HAND1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HAND1→partner) and Y-score (partner→HAND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RNA splicing, via transesterification reactions →	+0.045	+0.284	<.001	.009	3	6
SKIN	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.039	+0.063	.005	.009	3	6
SKIN	mRNA splicing, via spliceosome →	+0.039	+0.063	.005	.009	3	6
LUNG_NSCLC_LUAD	Positive regulation of protein localization to nucleus →	+0.038	+0.122	.005	.006	3	4
LUNG_NSCLC_LUAD	Negative regulation of myoblast fusion →	+0.059	+0.170	<.001	.007	3	4
LUNG_NSCLC_LUAD	Regulation of G1/S transition of mitotic cell cycle →	+0.035	+0.107	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 311 associations by consensus.

RNA splicing, via transesterification reactions by HAND1 expression — OVARY

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