HAND1

Across TCGA cell cohorts, HAND1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HAND1-associated genes across cancer lineages are MS4A4A, CDX4, and RNF212B. Each is linked with HAND1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAND1-to-partner and partner-to-HAND1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A4A grouped by HAND1-low versus HAND1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAND1→partner) and Y-score (partner→HAND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MS4A4A →	+0.154	+3.678	<.001	.009	3	1
LARGE_INTESTINE	CDX4 →	+0.011	+4.217	<.001	.001	3	1
LARGE_INTESTINE	RNF212B →	+0.096	+3.678	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

MS4A4A by HAND1 expression — LARGE_INTESTINE

Explore this box plot interactively →