HAMP

Across TCGA patient cohorts, HAMP protein abundance is significantly associated with the RNA expression of many other genes, with 1,808 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HAMP-associated genes across cancer lineages are PLSCR4, SLN, and STAB1. Each is linked with HAMP in more than 2 cancer types. Because this analysis shows association rather than direction, both HAMP-to-partner and partner-to-HAMP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HAMP versus PLSCR4 in BRCA, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAMP→partner) and Y-score (partner→HAMP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PLSCR4 →	+1.122	+1.514	<.001	.009	3	2
HNSC	SLN →	+4.029	+0.617	.002	<.001	3	2
HNSC	STAB1 →	+0.953	+0.351	.005	.004	3	2
HNSC	PRUNE2 →	+1.844	+0.553	.008	<.001	2	3
HNSC	ARID3A →	+0.548	+0.335	.006	.007	3	2
HNSC	TCTEX1D1 →	+0.610	+0.519	.007	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,808 associations by consensus.

HAMP vs PLSCR4 — BRCA

Explore this scatter interactively →