HAMP

Across TCGA cell cohorts, HAMP RNA expression is significantly associated with the go_rna of many other GO terms, with 877 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible HAMP-associated GO terms across cancer lineages are Negative regulation of intestinal absorption, Mycotoxin metabolic process, and Aflatoxin metabolic process. Each is linked with HAMP in more than 16 cancer types. Because this analysis shows association rather than direction, both HAMP-to-partner and partner-to-HAMP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of intestinal absorption grouped by HAMP-low versus HAMP-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HAMP→partner) and Y-score (partner→HAMP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of intestinal absorption →	+1.837	+5.237	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Mycotoxin metabolic process →	-0.250	-0.850	<.001	.006	3	5
UPPER_AERODIGESTIVE_TRACT	Aflatoxin metabolic process →	-0.250	-0.850	<.001	.006	3	5
BLOOD_Leukemia	Desmosome organization →	+0.785	+0.117	.001	.004	3	4
BLOOD_Leukemia	Bundle of His cell-Purkinje myocyte adhesion involved in cell communication →	+0.811	+0.104	<.001	.001	3	4
OVARY	Serotonin secretion →	+0.725	+0.038	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 877 associations by consensus.

Negative regulation of intestinal absorption by HAMP expression — LIVER

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