HAL

Across TCGA pan-cancer cohorts, HAL mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated HAL data layer compared with 20 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HAL mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated HAL expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC are the cancer types where HAL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.883	0.458	.005	11	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

HAL–HNSC (OS)

Open the HNSC breakdown →