HAL

Across TCGA patient cohorts, HAL mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAL-associated genes across cancer lineages are eEF2, EGFR_pY1068, and Gab2. Each is linked with HAL in more than 1 cancer types. Because this analysis shows association rather than direction, both HAL-to-partner and partner-to-HAL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by HAL-low versus HAL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAL→partner) and Y-score (partner→HAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.444	+2.169	<.001	.003	3	2
UCEC	EGFR_pY1068 →	-0.357	-2.662	<.001	<.001	3	2
UCEC	Gab2 →	+0.388	+2.115	.003	.017	3	2
UCEC	INPP4B →	-0.266	-2.222	.028	.009	3	2
UCEC	JNK_pT183_Y185 →	-0.172	-1.752	.006	.014	3	2
UCEC	N-Ras →	-0.113	-3.295	.011	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

eEF2 by HAL expression — UCEC

Explore this box plot interactively →