HAL

Across TCGA cell cohorts, HAL RNA expression is significantly associated with the go_rna of many other GO terms, with 2,945 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HAL-associated GO terms across cancer lineages are Vacuolar transport, Cytotoxic T cell degranulation, and Pre-mRNA catabolic process. Each is linked with HAL in more than 7 cancer types. Because this analysis shows association rather than direction, both HAL-to-partner and partner-to-HAL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vacuolar transport grouped by HAL-low versus HAL-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HAL→partner) and Y-score (partner→HAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Vacuolar transport →	+0.043	+0.495	<.001	.002	3	8
BONE	Cytotoxic T cell degranulation →	+0.254	+0.353	.001	.006	3	7
BONE	Pre-mRNA catabolic process →	+0.208	+0.444	.006	.004	3	7
LUNG_SCLC	Lysosomal transport →	+0.042	+0.514	.001	.001	3	7
BONE	Cytoplasm protein quality control →	+0.127	+0.463	<.001	.001	3	6
UPPER_AERODIGESTIVE_TRACT	Viral translational termination-reinitiation →	+0.086	+0.245	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,945 associations by consensus.

Vacuolar transport by HAL expression — LUNG_SCLC

Explore this box plot interactively →