HAL

Across TCGA cell cohorts, HAL mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HAL-associated genes across cancer lineages are CST9, SPATA31A5, and OR1L3. Each is linked with HAL in more than 1 cancer types. Because this analysis shows association rather than direction, both HAL-to-partner and partner-to-HAL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST9 grouped by HAL-low versus HAL-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAL→partner) and Y-score (partner→HAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CST9 →	+0.046	+4.981	<.001	.008	3	1
CNS	SPATA31A5 →	+0.029	+5.321	<.001	.005	3	1
OVARY	OR1L3 →	+0.034	+4.029	.002	.009	3	1
OVARY	CCDC60 →	+0.064	+4.228	<.001	.006	3	1
OVARY	C1orf146 →	+0.040	+4.450	<.001	.004	3	1
SKIN	ENPP7 →	+0.006	+5.415	.007	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

CST9 by HAL expression — CNS

Explore this box plot interactively →