HADHB

Across TCGA pan-cancer cohorts, HADHB Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HADHB data layer compared with 17 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HADHB Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated HADHB expression acts as an unfavorable survival marker.

HNSC, CESC, and BLCA are the cancer types where HADHB Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.140	0.698	<.001	59	view →
CESC	OS	Median	All	0.047	0.875	<.001	24	view →
BLCA	OS	Median	III,IV	0.153	0.684	.001	21	view →
SKCM	DFS	Median	All	0.290	0.759	.010	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HADHB–HNSC (DFS)

Open the HNSC breakdown →