HADHB

Across TCGA pan-cancer cohorts, HADHB mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HADHB data layer compared with 17 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher HADHB mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HADHB expression acts as an unfavorable survival marker.

LUAD, LSCC, and PDAC are the cancer types where HADHB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.644	0.874	.004	16	view →
LSCC	DFS	Quartile	All	0.694	0.961	.003	16	view →
PDAC	DFS	Quartile	III,IV	0.195	0.961	.004	15	view →
CCRCC	DFS	Median	III,IV	0.390	0.781	.005	7	view →
HNSC	DFS	Tertile	II,III,IV	0.915	0.991	.041	4	view →
UCEC	DFS	Median	All	0.936	1.000	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HADHB–LUAD (OS)

Open the LUAD breakdown →