HADHA

Across TCGA pan-cancer cohorts, HADHA mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HADHA data layer compared with 20 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HADHA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HADHA expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

CCRCC, UCEC, and PDAC are the cancer types where HADHA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	II,III,IV	0.250	0.750	.003	10	view →
UCEC	DFS	Quartile	II,III,IV	0.453	1.000	.018	10	view →
PDAC	OS	Quartile	All	0.473	0.282	.018	8	view →
LUAD	DFS	Tertile	II,III,IV	0.331	0.639	.023	5	view →
LSCC	DFS	Quartile	All	0.679	0.923	.013	5	view →
HNSC	DFS	Tertile	III,IV	0.912	0.736	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HADHA–CCRCC (DFS)

Open the CCRCC breakdown →