HADHA

Across TCGA patient cohorts, HADHA mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HADHA-associated genes across cancer lineages are ASNS, Notch1, and ATM. Each is linked with HADHA in more than 2 cancer types. Because this analysis shows association rather than direction, both HADHA-to-partner and partner-to-HADHA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by HADHA-low versus HADHA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HADHA→partner) and Y-score (partner→HADHA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.384	+2.321	.005	.033	3	3
UCEC	Notch1 →	+0.190	+2.584	<.001	.001	3	2
UCEC	ATM →	-0.352	-1.678	.043	.023	3	2
UCEC	4E-BP1 →	+0.308	+3.247	.003	<.001	3	2
UCEC	Cyclin-B1 →	+0.509	+3.321	.018	.009	3	2
UCEC	EGFR_pY1068 →	-0.259	-2.087	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

ASNS by HADHA expression — UCEC

Explore this box plot interactively →