HADHA

Across TCGA cell cohorts, HADHA RNA expression is significantly associated with the go_rna of many other GO terms, with 3,827 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HADHA-associated GO terms across cancer lineages are Peroxisome proliferator activated receptor signaling pathway, Synaptic vesicle lumen acidification, and Phosphatidylinositol acyl-chain remodeling. Each is linked with HADHA in more than 8 cancer types. Because this analysis shows association rather than direction, both HADHA-to-partner and partner-to-HADHA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peroxisome proliferator activated receptor signaling pathway grouped by HADHA-low versus HADHA-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HADHA→partner) and Y-score (partner→HADHA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Peroxisome proliferator activated receptor signaling pathway →	+0.077	+0.925	.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Synaptic vesicle lumen acidification →	+0.100	+0.791	<.001	.005	3	9
PANCREAS	Phosphatidylinositol acyl-chain remodeling →	+0.153	+0.879	<.001	.003	3	9
SKIN	1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process →	+0.097	+0.413	<.001	<.001	3	8
LUNG_NSCLC_LUSC	Positive regulation of bicellular tight junction assembly →	-0.210	-0.592	.001	.009	3	8
LUNG_NSCLC_LUSC	Quinone metabolic process →	+0.072	+0.565	<.001	.007	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,827 associations by consensus.

Peroxisome proliferator activated receptor signaling pathway by HADHA expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →