HADHA

Across TCGA cell cohorts, HADHA mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HADHA-associated genes across cancer lineages are OR4D2, ACSM6, and CFHR2. Each is linked with HADHA in more than 1 cancer types. Because this analysis shows association rather than direction, both HADHA-to-partner and partner-to-HADHA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4D2 grouped by HADHA-low versus HADHA-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HADHA→partner) and Y-score (partner→HADHA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR4D2 →	+0.019	+5.029	<.001	.006	3	1
LARGE_INTESTINE	ACSM6 →	+0.022	+3.584	<.001	.002	3	1
LARGE_INTESTINE	CFHR2 →	+0.032	+3.700	<.001	.009	3	1
BLOOD_Leukemia	GPR26 →	+0.077	+5.539	<.001	.003	3	1
BLOOD_Leukemia	SCGB3A2 →	+0.144	+4.922	<.001	.009	3	1
BLOOD_Leukemia	MRGPRX4 →	+0.012	+4.922	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

OR4D2 by HADHA expression — LUNG_SCLC

Explore this box plot interactively →