HADH

Across TCGA pan-cancer cohorts, HADH mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HADH data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher HADH mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HADH expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, HNSC, and CCRCC are the cancer types where HADH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.862	0.553	<.001	55	view →
HNSC	DFS	Tertile	All	1.000	0.220	.021	12	view →
CCRCC	OS	Median	IV	1.000	0.451	.016	10	view →
LSCC	DFS	Quartile	All	0.593	0.862	.019	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HADH–PDAC (DFS)

Open the PDAC breakdown →