HADH

Across TCGA patient cohorts, HADH mutation is significantly associated with the RNA expression of many other genes, with 2,635 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HADH-associated genes across cancer lineages are MIR138-1, RN7SKP263, and RNU2-13P. Each is linked with HADH in more than 1 cancer types. Because this analysis shows association rather than direction, both HADH-to-partner and partner-to-HADH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR138-1 grouped by HADH-low versus HADH-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HADH→partner) and Y-score (partner→HADH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MIR138-1 →	+0.396	+4.925	<.001	.004	3	2
LUSC	RN7SKP263 →	+0.135	+5.309	.002	.003	3	2
LUSC	RNU2-13P →	+0.310	+5.081	<.001	.004	3	2
HNSC	RN7SL254P →	+0.488	+5.303	<.001	.006	3	2
HNSC	KRTAP4-16 →	+0.064	+5.578	<.001	.004	3	2
BLCA	MIR3137 →	+0.648	+5.788	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,635 associations by consensus.

MIR138-1 by HADH expression — READ

Explore this box plot interactively →