HADH

Across TCGA cell cohorts, HADH mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HADH-associated genes across cancer lineages are C9orf92, CLRN2, and SLC5A8. Each is linked with HADH in more than 1 cancer types. Because this analysis shows association rather than direction, both HADH-to-partner and partner-to-HADH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf92 grouped by HADH-low versus HADH-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HADH→partner) and Y-score (partner→HADH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C9orf92 →	+0.194	+5.369	<.001	.004	3	1
SOFT_TISSUE	CLRN2 →	+0.015	+5.369	.007	.004	3	1
SOFT_TISSUE	SLC5A8 →	+0.006	+4.930	<.001	.008	3	1
SKIN	IL31 →	+0.028	+4.977	<.001	.007	3	1
SKIN	C3orf56 →	+0.006	+4.977	<.001	.007	3	1
LARGE_INTESTINE	GJD2 →	+0.004	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

C9orf92 by HADH expression — SOFT_TISSUE

Explore this box plot interactively →