HACL1

Across TCGA pan-cancer cohorts, HACL1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HACL1 data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HACL1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HACL1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where HACL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.584	0.831	<.001	15	view →
LUAD	OS	Tertile	II,III,IV	0.266	0.765	.007	15	view →
CCRCC	DFS	Median	III,IV	1.000	0.809	.012	9	view →
PDAC	OS	Quartile	All	0.268	0.581	.013	3	view →
LSCC	DFS	Quartile	II,III,IV	0.200	1.000	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HACL1–HNSC (OS)

Open the HNSC breakdown →