HACL1

Across TCGA patient cohorts, HACL1 protein abundance is significantly associated with the RNA expression of many other genes, with 7,149 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HACL1-associated genes across cancer lineages are PDE1C, GPRASP2, and PTGIS. Each is linked with HACL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both HACL1-to-partner and partner-to-HACL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HACL1 versus PDE1C in GBM, with a Pearson correlation of -0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HACL1→partner) and Y-score (partner→HACL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PDE1C →	-0.735	-0.256	<.001	.001	3	4
UCEC	GPRASP2 →	-0.538	-0.428	<.001	<.001	3	4
UCEC	PTGIS →	-1.449	-0.601	<.001	<.001	3	3
CCRCC	THRA →	-0.559	-0.380	<.001	<.001	3	3
UCEC	RAMP1 →	-1.306	-0.331	<.001	.002	3	3
GBM	BEX1 →	-1.399	-0.411	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,149 associations by consensus.

HACL1 vs PDE1C — GBM

Explore this scatter interactively →