HACL1

Across TCGA patient cohorts, HACL1 mutation is significantly associated with the RNA expression of many other genes, with 963 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HACL1-associated genes across cancer lineages are PAICSP2, RN7SL823P, and MIR4510. Each is linked with HACL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HACL1-to-partner and partner-to-HACL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAICSP2 grouped by HACL1-low versus HACL1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HACL1→partner) and Y-score (partner→HACL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	PAICSP2 →	+0.053	+5.196	.003	.001	3	2
CESC	RN7SL823P →	+0.372	+4.193	<.001	.009	3	2
CESC	MIR4510 →	+0.297	+5.342	<.001	.002	3	2
CESC	CCND3P2 →	+0.057	+5.569	<.001	.002	3	2
CESC	MIR3135A →	+0.460	+4.503	.001	.005	3	2
STAD	RN7SL544P →	+0.102	+5.187	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 963 associations by consensus.

PAICSP2 by HACL1 expression — CESC

Explore this box plot interactively →