HACL1

Across TCGA cell cohorts, HACL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,008 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible HACL1-associated GO terms across cancer lineages are Regulation of Wnt protein secretion, Positive regulation of Wnt protein secretion, and Methyl-branched fatty acid metabolic process. Each is linked with HACL1 in more than 9 cancer types. Because this analysis shows association rather than direction, both HACL1-to-partner and partner-to-HACL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of Wnt protein secretion grouped by HACL1-low versus HACL1-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HACL1→partner) and Y-score (partner→HACL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of Wnt protein secretion →	+0.057	+0.577	.006	.002	3	10
SKIN	Positive regulation of Wnt protein secretion →	+0.050	+0.549	.009	.003	3	10
OESOPHAGUS	Methyl-branched fatty acid metabolic process →	+0.218	+1.062	.001	.002	3	9
PANCREAS	Mitochondrial mRNA catabolic process →	+0.125	+0.960	.002	<.001	3	9
SOFT_TISSUE	Biotin metabolic process →	+0.075	+0.865	.001	.001	3	9
KIDNEY	mRNA 3'-splice site recognition →	+0.159	+1.300	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,008 associations by consensus.

Regulation of Wnt protein secretion by HACL1 expression — SKIN

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