Across TCGA pan-cancer cohorts, HACD4 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated HACD4 data layer compared with 22 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher HACD4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated HACD4 expression acts as an unfavorable survival marker.

READ and SKCM are the cancer types where HACD4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Median	All	0.182	0.819	.004	18	view →
SKCM	OS	Median	III,IV	0.245	0.721	.018	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: HACD4 tumor-vs-normal RNA expression · all HACD4 data types