Across TCGA pan-cancer cohorts, HACD4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HACD4 data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher HACD4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HACD4 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

LSCC, LUAD, and CCRCC are the cancer types where HACD4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.553	0.893	.007	30	view →
LUAD	OS	Median	II,III,IV	0.825	0.356	.001	10	view →
CCRCC	DFS	Median	II,III,IV	1.000	0.331	.045	2	view →
HNSC	DFS	Quartile	II,III,IV	0.861	1.000	.029	2	view →
PDAC	OS	Median	All	0.927	0.705	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: HACD4 tumor-vs-normal RNA expression · all HACD4 data types