Across TCGA patient cohorts, HACD4 mutation is significantly associated with the RNA expression of many other genes, with 509 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HACD4-associated genes across cancer lineages are ZNHIT3, RNA5SP414, and TUBGCP5. Each is linked with HACD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HACD4-to-partner and partner-to-HACD4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HACD4→partner) and Y-score (partner→HACD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNHIT3 →	+0.545	+3.245	.002	.008	3	1
UCEC	RNA5SP414 →	+0.557	+2.577	<.001	.004	3	1
UCEC	TUBGCP5 →	+0.463	+3.370	.009	.005	3	1
UCEC	UHRF1 →	+1.153	+3.595	<.001	.001	3	1
UCEC	STMN1P1 →	+0.420	+2.693	.003	.009	3	1
UCEC	RNA5SP411 →	+1.109	+2.171	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 509 associations by consensus.

Exploration

HACD4 survival (RNA) · tumor vs normal (RNA) · all HACD4 data types